https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40957 Wed 20 Jul 2022 16:04:20 AEST ]]> Going beyond antibiotics: natural plant extracts as an emergent strategy to combat biofilm-associated infections https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40187 Wed 20 Jul 2022 14:17:50 AEST ]]> Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38204 Wed 18 Aug 2021 09:53:13 AEST ]]> Central composite designed formulation, characterization and in vitro cytotoxic effect of erlotinib loaded chitosan nanoparticulate system https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48347 Wed 15 Mar 2023 08:25:44 AEDT ]]> Perfluorocarbons therapeutics in modern cancer nanotechnology for hypoxia-induced anti-tumor therapy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53709 Wed 10 Jan 2024 11:02:51 AEDT ]]> Antibacterial and antioxidant potential of biosynthesized copper nanoparticles mediated through Cissus arnotiana plant extract https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36822 Cissus arnotiana and evaluated their antibacterial activity against gram negative and gram positive bacteria. The morphology and characterization of the synthesized CuNPs were studied and done using UV-Visible spectroscopy at a wavelength range of 350–380 nm. XRD studies were performed for analyzing the crystalline nature; SEM and TEM for evaluating the spherical shape within the size range of 60–90 nm and AFM was performed to check the surface roughness. The biosynthesized CuNPs showed better antibacterial activity against the gram-negative bacteria, E. coli with an inhibition zone of 22.20 ± 0.16 mm at 75 μg/ml. The antioxidant property observed was comparatively equal with the standard antioxidant agent ascorbic acid at a maximum concentration of 40 μg/ ml. This is the first study reported on C. arnotiana mediated biosynthesis of copper nanoparticles, where we believe that the findings can pave way for a new direction in the field of nanotechnology and nanomedicine where there is a significant potential for antibacterial and antioxidant activities. We predict that, these could lead to an exponential increase in the field of biomedical applications, with the utilization of green synthesized CuNPs, due to its remarkable properties. The highest antibacterial property was observed with gram-negative strains mainly, E. coli, due to its thin peptidoglycan layer and electrostatic interactions between the bacterial cell wall and CuNPs surfaces. Hence, CuNPs can be potent therapeutic agents in several biomedical applications, which are yet to be explored in the near future.]]> Wed 08 Jul 2020 13:55:41 AEST ]]> Small interfering RNA for cancer treatment: overcoming hurdles in delivery https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43998 Wed 05 Oct 2022 15:10:41 AEDT ]]> Hypoxia-inducible factor (HIF): Fuel for cancer progression https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53287 Tue 21 Nov 2023 10:23:37 AEDT ]]> An overview of vaccine development for COVID-19 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46318 Tue 15 Nov 2022 11:45:52 AEDT ]]> Hybrid molecules based on 1,3,5-triazine as potential therapeutics: a focused review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39877 Thu 14 Jul 2022 13:40:35 AEST ]]> Emerging trends in the novel drug delivery approaches for the treatment of lung cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36704 Thu 09 Dec 2021 11:02:25 AEDT ]]> Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38487 Thu 07 Oct 2021 16:37:12 AEDT ]]> Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46614 Mon 28 Nov 2022 10:43:30 AEDT ]]> Preparation, characterization and in-vitro efficacy of quercetin loaded liquid crystalline nanoparticles for the treatment of asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42171 Fri 26 Aug 2022 08:02:59 AEST ]]> Albumin nano-encapsulation of piceatannol enhances its anticancer potential in colon cancer via downregulation of nuclear p65 and HIF-1 alpha https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38456 Fri 17 Sep 2021 15:35:08 AEST ]]> Emerging therapeutic potential of the iridoid molecule, asperuloside: a snapshot of its underlying molecular mechanisms https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46115 Fri 11 Nov 2022 14:39:50 AEDT ]]> Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45754 90%), and negative zeta potential (−1.42 ± 0.25% mV) values. ME hydrogel composite with optimum rheological and textural attributes showed better permeation, retention, and skin-compliant characteristics, vis-a-vis marketed formulation (Aziderm™) when evaluated in Wistar rat skin. In vitro antibacterial efficacy in bacterial strains, i.e., Staphylococcus aureus, Propionibacterium acne, and Staphylococcus epidermidis, was evaluated employing agar well plate diffusion and broth dilution assay. ME hydrogel has shown an increase in zone of inhibition by two folds and a decrease in minimum inhibitory concentration (MIC) by eightfold against P. acnes vis-a-vis AzA. Finally, ME hydrogel composite exhibited a better reduction in the papule density (93.75 ± 1.64%) in comparison to Aziderm™ 72.69 ± 4.67%) on acne as developed in rats by inducing testosterone. Thus, the developed AzA-TTO ME hydrogel composite promises an efficacious and comparatively safer drug delivery system for the topical therapy of acne vulgaris.]]> Fri 04 Nov 2022 10:41:04 AEDT ]]>